10074-G5, CAS [[413611-93-5]]

Product Overview

• Article Name: 10074-G5, CAS [[413611-93-5]]
• Biozol Catalog Number: FBM-10-5627
• Supplier Catalog Number: 10-5627
• Alternative Catalog Number: FBM-10-5627-5MG,FBM-10-5627-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

c-Myc inhibitor

Product Properties

• Molecular Weight: 332.32
• Purity: 98% by TLC NMR (Conforms)
• Form: Orange solid
• CAS Number: [413611-93-5]
• Formula: C18H12N4O3

Application Notes

• Application Notes: Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity.1 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 mM.1 It was cytotoxic in C-Myc-overexpressing cell lines (IC50s = 13 to 15 mM) but was not active in vivo due to rapid metabolism.2 10074-G5 is a useful tool to probe for involvement of c-Myc involvement in cellular processes.3,4 Binds to and sequesters the intrinsically disordered amyloid-beta (Abeta) in its monomeric soluble state and rescues a C. elegans model of Abeta-associated toxicity.5