BG45, CAS [[926259-99-6]]

Produktübersicht

• Artikelname: BG45, CAS [[926259-99-6]]
• Artikelnummer: FBM-10-5638
• Hersteller Artikelnummer: 10-5638
• Alternativnummer: FBM-10-5638-5MG, FBM-10-5638-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(2-Aminophenyl)-2-pyrazinecarboxamide

Produktbeschreibung

HDAC3 selective inhibitor

Produkteigenschaften

• Molekulargewicht: 214.23
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Beige solid
• CAS Nummer: [926259-99-6]
• Formel: C11H10N4O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 mM respectively.1 Inhibits tumor growth in a mouse xenograft model of human multiple myeloma.1 Downregulates expression of DNA methyltransferase 1.2 Increases expression of synaptic proteins in exogenous Abeta-treated cells and mice.3 Rescues synaptic damage and neuron loss in APP-transfected cells (15 mM) and APP/PS1 mice (30 mg/kg).4