PF-2545920 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10A), IC50 = 0.37 nM.1 Active in a number of animal models for antipsychotic activity.2 Suppresses microglial activation in LPA-induced neuroinflammation and MPTP-induced Parkinsons disease models.3 Suppresses proliferation of human glioblastoma cells.4 Novel agent for stimulation of sperm motility.5 Brain penetrant.
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