Ro 5-3335, CAS [[30195-30-3]]

Produktübersicht

• Artikelname: Ro 5-3335, CAS [[30195-30-3]]
• Artikelnummer: FBM-10-5887
• Hersteller Artikelnummer: 10-5887
• Alternativnummer: FBM-10-5887-5MG, FBM-10-5887-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one

Produktbeschreibung

RUNX1 transcription factor inhibitor

Produkteigenschaften

• Molekulargewicht: 259.69
• Reinheit: >98% by TLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [30195-30-3]
• Formel: C13H10ClN3O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Ro 5-3335 was identified in a screen for inhibitors of the RUNX1-CBFbeta interaction. It represses RUNX1/CBFB-dependent transactivation in reporter assays and runx1-dependent hematopoiesis in zebrafish embryos.1 Ro 5-3335 slows disease progression in various models including acute kidney injury2, acute myocardial infarction3 and osteoarthritis4 among others5. It synergizes with an HDAC inhibitor enhancing the activation of latent HIV-1 in both cell lines and patient PBMCs.6