Ro 5-3335, CAS [[30195-30-3]]

Product Overview

• Article Name: Ro 5-3335, CAS [[30195-30-3]]
• Biozol Catalog Number: FBM-10-5887
• Supplier Catalog Number: 10-5887
• Alternative Catalog Number: FBM-10-5887-5MG,FBM-10-5887-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

RUNX1 transcription factor inhibitor

Product Properties

• Molecular Weight: 259.69
• Purity: >98% by TLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [30195-30-3]
• Formula: C13H10ClN3O

Application Notes

• Application Notes: Ro 5-3335 was identified in a screen for inhibitors of the RUNX1-CBFbeta interaction. It represses RUNX1/CBFB-dependent transactivation in reporter assays and runx1-dependent hematopoiesis in zebrafish embryos.1 Ro 5-3335 slows disease progression in various models including acute kidney injury2, acute myocardial infarction3 and osteoarthritis4 among others5. It synergizes with an HDAC inhibitor enhancing the activation of latent HIV-1 in both cell lines and patient PBMCs.6