PD 0325901 is a potent MEK1 and MEK2 inhibitor, which inhibits MEK activity in mouse colon cells with an IC50 of 0.33 nM. PD 0325901 inhibits growth and proliferation of a variety of cancer cells in vitro, also inhibiting production of proangiogenic cytokines such as VEGF. In vivo, PD 032901 induces G1-phase cell cycle arrest and apoptosis in a cancer model and promotes myelin recovery in drug-induced demyelination in vivo in mice. PD 0325901 enhances generation of induced pluripotent stem cells (iPSCs) and in combination with CHIR 99021 and A 83-01 induces generation of ground state iPS cells from human and rat somatic cells.
Molekulargewicht:
482.2
Reinheit:
98% by hplc. NMR conforms
Formulierung:
White solid
CAS Nummer:
[391210-10-9]
Formel:
C16H14F3IN2O4
Target-Kategorie:
Kinases
Anwendungsbeschreibung:
ProductType: Small molecules
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