WaTx

Produktübersicht

• Artikelname: WaTx
• Artikelnummer: ISC-PN-120
• Hersteller Artikelnummer: PN-120
• Alternativnummer: ISC-PN-120
• Hersteller: Isca Biochemicals
• Kategorie: Biochemikalien
• Alternative Synonym: Wasabi receptor toxin

Produktbeschreibung

WaTx, also known as wasabi receptor toxin, is the active component of the venom of the Australian black rock scorpion Urodacus manicatus. WaTx targets the mechanical and chemical stress sensor transient receptor potential cation channel 1 (TRPA1), which it stabilizes in an active state characterized by prolonged channel openings and low Ca2+ permeability. WaTx elicits acute pain and pain hypersensitivity, but fails to trigger efferent release of neuropeptides and neurogenic inflammation typically produced by other toxins. WaTx is a unique pharmacological probe for dissecting TRPA1 function and its contribution to acute and persistent pain.

Produkteigenschaften

• Molekulargewicht: 3855.3
• NCBI: 2019
• Reinheit: >95% by HPLC
• Formulierung: Freeze dried solid
• Sequenz: H-Ala-Ser-Pro-Gln-Gln-Ala-Lys-Tyr-Cys-Tyr-Glu-Gln-Cys-Asn-Val-Asn-Lys-Val-Pro-Phe-Asp-Gln-Cys-Tyr-Gln-Met-Cys-Ser-Pro-Leu-Glu-Arg-Ser-OH (disulphide bridge between C9 and C27 and C13 and C23)
• Formel: C164H245N45O53S5
• Target-Kategorie: Transient receptor potential (TRP) channels

Anwendungsbeschreibung

• Anwendungsbeschreibung: ProductType: Peptides