SB 431542, CAS [[301836-41-9]]

Produktübersicht

• Artikelname: SB 431542, CAS [[301836-41-9]]
• Artikelnummer: ISC-RK-030
• Hersteller Artikelnummer: RK-030
• Alternativnummer: ISC-RK-030
• Hersteller: Isca Biochemicals
• Kategorie: Biochemikalien
• Alternative Synonym: TGF-beta RI Kinase Inhibitor VI

Produktbeschreibung

SB 431542 is a potent and selective inhibitor of the transforming growth factor-beta (TGF-beta) type I receptor/ALK5, with an IC50 value of 94 nM, and also inhibits the related ALK4 and ALK7. SB 431542 inhibits TGF-beta-induced epithelial to mesenchymal transition (EMT) migration, invasion and VEGF secretion in several human cancer cell lines, and suppresses TGF-beta-induced proliferation of human osteosarcoma cells. SB 431542 can replace SOX2 in reprogramming of fibroblasts into induced pluripotent stem cells (iPSCs) and can also be used in a protocol to generate brain organoids from human iPSCs.

Produkteigenschaften

• Molekulargewicht: 384.4
• Reinheit: 99% by hplc, NMR conforms
• CAS Nummer: [301836-41-9]
• Formel: C22H16N4O3
• Target-Kategorie: Receptor serine/threonine kinase receptors

Anwendungsbeschreibung

• Anwendungsbeschreibung: ProductType: Small molecules