SB 431542 is a potent and selective inhibitor of the transforming growth factor-beta (TGF-beta) type I receptor/ALK5, with an IC50 value of 94 nM, and also inhibits the related ALK4 and ALK7. SB 431542 inhibits TGF-beta-induced epithelial to mesenchymal transition (EMT) migration, invasion and VEGF secretion in several human cancer cell lines, and suppresses TGF-beta-induced proliferation of human osteosarcoma cells. SB 431542 can replace SOX2 in reprogramming of fibroblasts into induced pluripotent stem cells (iPSCs) and can also be used in a protocol to generate brain organoids from human iPSCs.
Molecular Weight:
384.4
Purity:
99% by hplc, NMR conforms
CAS Number:
[301836-41-9]
Formula:
C22H16N4O3
Target:
Receptor serine/threonine kinase receptors
Application Notes:
ProductType: Small molecules
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