DFMTI can completely block the rmGlu1 L757V glutamate response. In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade. In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.
Molekulargewicht:
368.38
Reinheit:
99.04
CAS Nummer:
[864864-86-8]
Formel:
C20H18F2N4O
Target-Kategorie:
mGluR
Anwendungsbeschreibung:
Reference compound
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