DFMTI can completely block the rmGlu1 L757V glutamate response. In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade. In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.
Molecular Weight:
368.38
Purity:
99.04
CAS Number:
[864864-86-8]
Formula:
C20H18F2N4O
Target:
mGluR
Application Notes:
Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted