TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-kappaB pathway activation and promotes apoptosis[1][2].
Molekulargewicht:
519.52
Reinheit:
98.38
CAS Nummer:
[1450833-55-2]
Formel:
C19H20F3N5O5S2
Target-Kategorie:
Apoptosis,E1/E2/E3 Enzyme,NF-kappaB
Anwendungsbeschreibung:
MCE Product type: Reference compound
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