Landiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of beta1 adrenergic receptors. Landiolol hydrochloride specifically blocks cardiac beta1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-alpha-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury[1][2][3].
Molekulargewicht:
546.05
Reinheit:
99.96
CAS Nummer:
[144481-98-1]
Formel:
C25H40ClN3O8
Target-Kategorie:
Adrenergic Receptor,Calcium Channel,Potassium Channel,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
Reference compound
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