IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis[1][2].
Molekulargewicht:
221.26
Reinheit:
99.06
CAS Nummer:
[404009-40-1]
Formel:
C12H15NO3
Target-Kategorie:
Apoptosis,DNA-PK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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