Ritlecitinib (malonate), CAS [[2140301-97-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: Ritlecitinib (malonate), CAS [[2140301-97-7]] Preis auf Anfrage
• Artikelnummer: MCE-HY-100754A
• Hersteller Artikelnummer: HY-100754A
• Alternativnummer: MCE-HY-100754A-10MG,MCE-HY-100754A-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: PF-06651600 (malonate)

Produktbeschreibung

Ritlecitinib (PF-06651600) malonate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 µ M). Ritlecitinib malonate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib malonate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE)[1][2][3].

Produkteigenschaften

• Molekulargewicht: 389.41
• CAS Nummer: [2140301-97-7]
• Formel: C18H23N5O5
• Target-Kategorie: Interleukin Related,JAK,STAT

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound