Ritlecitinib (malonate), CAS [[2140301-97-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-100754A
Supplier Catalog Number:
HY-100754A
Alternative Catalog Number:
MCE-HY-100754A-10MG,MCE-HY-100754A-5MG
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
PF-06651600 (malonate)
Ritlecitinib (PF-06651600) malonate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 µ M). Ritlecitinib malonate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib malonate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE)[1][2][3].
Molecular Weight:
389.41
CAS Number:
[2140301-97-7]
Formula:
C18H23N5O5
Target:
Interleukin Related,JAK,STAT
Application Notes:
MCE Product type: Reference compound
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