CHMFL-EGFR-202, CAS [[2089381-40-6]]

Produktübersicht

• Artikelname: CHMFL-EGFR-202, CAS [[2089381-40-6]]
• Artikelnummer: MCE-HY-101522
• Hersteller Artikelnummer: HY-101522
• Alternativnummer: MCE-HY-101522-1MG,MCE-HY-101522-10MG,MCE-HY-101522-10MMX1ML,MCE-HY-101522-25MG,MCE-HY-101522-100MG,MCE-HY-101522-5MG,MCE-HY-101522-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ~10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent DFG-in-C-helix-out inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines[1].

Produkteigenschaften

• Molekulargewicht: 489.96
• Reinheit: 99.75
• CAS Nummer: [2089381-40-6]
• Formel: C25H24ClN7O2
• Target-Kategorie: BMX Kinase,Btk,EGFR,MEK

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound