CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ~10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent DFG-in-C-helix-out inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines[1].
Molecular Weight:
489.96
Purity:
99.75
CAS Number:
[2089381-40-6]
Formula:
C25H24ClN7O2
Target:
BMX Kinase,Btk,EGFR,MEK
Application Notes:
MCE Product type: Reference compound
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