Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3alpha/beta inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/beta-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy[1][2][3].
Molekulargewicht:
501.80
Reinheit:
99.93
CAS Nummer:
[1797989-42-4]
Formel:
C22H19Cl3N8
Target-Kategorie:
Autophagy,GSK-3,Organoid,Wnt,beta-catenin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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