Sorafenib tosylate (Bay 43-9006 tosylate) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib tosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRbeta, FLT3 and c-Kit, respectively. Sorafenib tosylate induces autophagy and apoptosis. Sorafenib tosylate has anti-tumor activity. Sorafenib tosylate is a ferroptosis activator[1].
Molekulargewicht:
637.03
Reinheit:
99.98
CAS Nummer:
[475207-59-1]
Formel:
C28H24ClF3N4O6S
Target-Kategorie:
Apoptosis,Autophagy,Ferroptosis,FLT3,Raf,VEGFR
Anwendungsbeschreibung:
Reference compound
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