Sorafenib tosylate (Bay 43-9006 tosylate) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib tosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRbeta, FLT3 and c-Kit, respectively. Sorafenib tosylate induces autophagy and apoptosis. Sorafenib tosylate has anti-tumor activity. Sorafenib tosylate is a ferroptosis activator[1].
Molecular Weight:
637.03
Purity:
99.98
CAS Number:
[475207-59-1]
Formula:
C28H24ClF3N4O6S
Target:
Apoptosis,Autophagy,Ferroptosis,FLT3,Raf,VEGFR
Application Notes:
Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
