Ro 90-7501 is an amyloid beta42 (Abeta42) fibril assembly inhibitor that reduces Abeta42-induced cytotoxicity (EC50 of 2 µM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-beta gene expression and antiviral response[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner[3]. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells[4].
Molekulargewicht:
340.38
Reinheit:
99.10
CAS Nummer:
[293762-45-5]
Formel:
C20H16N6
Target-Kategorie:
Amyloid-beta,Apoptosis,ATM/ATR,Phosphatase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten