Ro 90-7501 is an amyloid beta42 (Abeta42) fibril assembly inhibitor that reduces Abeta42-induced cytotoxicity (EC50 of 2 µM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-beta gene expression and antiviral response[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner[3]. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells[4].
Molecular Weight:
340.38
Purity:
99.10
CAS Number:
[293762-45-5]
Formula:
C20H16N6
Target:
Amyloid-beta,Apoptosis,ATM/ATR,Phosphatase
Application Notes:
MCE Product type: Reference compound1
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