Pevonedistat hydrochloride, CAS [[1160295-21-5]]

Produktübersicht

• Artikelname: Pevonedistat hydrochloride, CAS [[1160295-21-5]]
• Artikelnummer: MCE-HY-10484
• Hersteller Artikelnummer: HY-10484
• Alternativnummer: MCE-HY-10484-1MG,MCE-HY-10484-10MMX1ML,MCE-HY-10484-50MG,MCE-HY-10484-5MG,MCE-HY-10484-10MG,MCE-HY-10484-100MG,MCE-HY-10484-200MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: MLN4924 (hydrochloride)

Produktbeschreibung

Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC50 of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice[1].

Produkteigenschaften

• Molekulargewicht: 479.98
• Reinheit: 99.19
• CAS Nummer: [1160295-21-5]
• Formel: C21H26ClN5O4S
• Target-Kategorie: Apoptosis,NEDD8-activating Enzyme

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound