Pevonedistat hydrochloride, CAS [[1160295-21-5]]

Product Overview

• Article Name: Pevonedistat hydrochloride, CAS [[1160295-21-5]]
• Biozol Catalog Number: MCE-HY-10484
• Supplier Catalog Number: HY-10484
• Alternative Catalog Number: MCE-HY-10484-1MG,MCE-HY-10484-10MMX1ML,MCE-HY-10484-50MG,MCE-HY-10484-5MG,MCE-HY-10484-10MG,MCE-HY-10484-100MG,MCE-HY-10484-200MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: MLN4924 (hydrochloride)

Product Description

Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC50 of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice[1].

Product Properties

• Molecular Weight: 479.98
• Purity: 99.19
• CAS Number: [1160295-21-5]
• Formula: C21H26ClN5O4S
• Target: Apoptosis,NEDD8-activating Enzyme

Application Notes

• Application Notes: MCE Product type: Reference compound