GSK1034702 (hydrochloride), CAS [[932373-86-9]] Preis auf Anfrage

Produktübersicht

• Artikelname: GSK1034702 (hydrochloride), CAS [[932373-86-9]] Preis auf Anfrage
• Artikelnummer: MCE-HY-107111A
• Hersteller Artikelnummer: HY-107111A
• Alternativnummer: MCE-HY-107111A-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

GSK1034702 hydrochloride is an orally active and allosteric agonist of M1 mAChR (pEC50=8.1) that can cross the blood-brain barrier. GSK1034702 hydrochloride activates the Gq/11 protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 hydrochloride can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 hydrochloride can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimers disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions)[1][2].

Produkteigenschaften

• Molekulargewicht: 369.86
• CAS Nummer: [932373-86-9]
• Formel: C18H25ClFN3O2
• Target-Kategorie: Cholinesterase (ChE),mAChR

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound