GSK1034702 (hydrochloride), CAS [[932373-86-9]] Preis auf Anfrage

Product Overview

• Article Name: GSK1034702 (hydrochloride), CAS [[932373-86-9]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-107111A
• Supplier Catalog Number: HY-107111A
• Alternative Catalog Number: MCE-HY-107111A-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

GSK1034702 hydrochloride is an orally active and allosteric agonist of M1 mAChR (pEC50=8.1) that can cross the blood-brain barrier. GSK1034702 hydrochloride activates the Gq/11 protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 hydrochloride can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 hydrochloride can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimers disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions)[1][2].

Product Properties

• Molecular Weight: 369.86
• CAS Number: [932373-86-9]
• Formula: C18H25ClFN3O2
• Target: Cholinesterase (ChE),mAChR

Application Notes

• Application Notes: MCE Product type: Reference compound