YM-244769 hydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice[1][2][3].
Molekulargewicht:
479.93
Reinheit:
99.02
CAS Nummer:
[837424-39-2]
Formel:
C26H23ClFN3O3
Target-Kategorie:
Na+/Ca2+ Exchanger
Anwendungsbeschreibung:
MCE Product type: Reference compound
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