Bisindolylmaleimide X hydrochloride(Ro 31-8425 hydrochloride, BIM-X hydrochloride) is a cell-penetrating PKC inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM. Bisindolylmaleimide X hydrochloride inhibits the proliferation of CD4 T cells in vitro. Bisindolylmaleimide X hydrochloride inhibits eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. Bisindolylmaleimide X hydrochloride can be used for research on the immune system and cardiovascular diseases[1][2][3].
Molekulargewicht:
460.96
Reinheit:
98.90
CAS Nummer:
[145317-11-9]
Formel:
C26H25ClN4O2
Target-Kategorie:
CDK,PKC
Anwendungsbeschreibung:
MCE Product type: Reference compound
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