Ischemin is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin also prevents apoptosis in ischemic cardiomyocytes. Ischemin can be used in the study of cardiovascular diseases (such as myocardial ischemia)[1].
Molekulargewicht:
335.38
Reinheit:
99.8
CAS Nummer:
[1357059-00-7]
Formel:
C15H17N3O4S
Target-Kategorie:
Apoptosis,Epigenetic Reader Domain,MDM-2/p53
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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