Ischemin is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin also prevents apoptosis in ischemic cardiomyocytes. Ischemin can be used in the study of cardiovascular diseases (such as myocardial ischemia)[1].
Molecular Weight:
335.38
Purity:
99.8
CAS Number:
[1357059-00-7]
Formula:
C15H17N3O4S
Target:
Apoptosis,Epigenetic Reader Domain,MDM-2/p53
Application Notes:
MCE Product type: Reference compound1
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