BX-513 is a highly potent and selective CCR1 antagonist. BX-513 effectively inhibits the binding of radiolabeled MIP-1alpha and RANTES to CCR1, with Ki values of 40 nM and 60 nM, respectively. BX-513 suppresses MIP-1alpha-induced extracellular acidification, MIP-1alpha- and RANTES-induced intracellular calcium mobilization, as well as MIP-1alpha- and RANTES-induced migration of peripheral blood mononuclear cells. BX-513 can be used for the research of rheumatoid arthritis and multiple sclerosis[1].
Molekulargewicht:
445.00
CAS Nummer:
[193542-65-3]
Formel:
C28H29ClN2O
Target-Kategorie:
CCR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
