BX-513 is a highly potent and selective CCR1 antagonist. BX-513 effectively inhibits the binding of radiolabeled MIP-1alpha and RANTES to CCR1, with Ki values of 40 nM and 60 nM, respectively. BX-513 suppresses MIP-1alpha-induced extracellular acidification, MIP-1alpha- and RANTES-induced intracellular calcium mobilization, as well as MIP-1alpha- and RANTES-induced migration of peripheral blood mononuclear cells. BX-513 can be used for the research of rheumatoid arthritis and multiple sclerosis[1].
Molecular Weight:
445.00
CAS Number:
[193542-65-3]
Formula:
C28H29ClN2O
Target:
CCR
Application Notes:
MCE Product type: Reference compound
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