Sitaxsentan sodium (IPI 1040 sodium, TBC11251 sodium) is a potent, selective and orally activeendothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium inhibits ET-1-induced phosphoinositide turnover. Sitaxsentan sodium can significantly alleviate pulmonary arterial hypertension (PAH) symptoms. Sitaxsentan sodium can be used for the study of PAH[1][2][3][4][5].
Molekulargewicht:
476.89
Reinheit:
98.83
CAS Nummer:
[210421-74-2]
Formel:
C18H14ClN2NaO6S2
Target-Kategorie:
Endothelin Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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