Tyk2-IN-5 (compound 6) is a potent, selective and orally active tyrosine kinase 2 (Tyk2) inhibitor that acts on the JH2 structural domain. Tyk2-IN-5 shows a Ki value of 0.086 nM for Tyk2 JH2 and an IC50 value of 25 nM for IFNalpha. Tyk2-IN-5 efficiently inhibits the production of IFNgamma in a pharmacodynamic rat model and is fully efficacious in a rat model of arthritis[1].
Molekulargewicht:
434.43
Reinheit:
99.35
CAS Nummer:
[1797432-62-2]
Formel:
C21H19FN8O2
Target-Kategorie:
JAK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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