JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) gamma-8, with a pIC50 of 9.7 for GluA1/gamma-8. Exhibits time- and dose-dependent AMPAR/gamma-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].
Molekulargewicht:
443.47
Reinheit:
99.18
CAS Nummer:
[2035814-50-5]
Formel:
C25H22FN5O2
Target-Kategorie:
iGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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