PROTAC RAR degrader-1 (Compound 9) is a potent and selective RAR PROTAC Degrader consisting of apoptotic protein inhibitors (IAPs) ligands. IAPs-based degraders are also known as SNIPERs. PROTAC RAR Degrader-1 reduces RARalpha levels in HT1080 cells in a concentration-dependent manner but is blocked by the proteasome inhibitor MG132 (HY-13259). PROTAC RAR Degrader-1 can be used in the study of nuclear receptor-related diseases. (Pink: RAR ligand 1 (HY-111843), Black: Linker (HY-140189), Blue: IAPs Ligand (HY-B0134))[1][2].
Molekulargewicht:
917.14
Reinheit:
97.91
CAS Nummer:
[1351169-27-1]
Formel:
C51H72N4O11
Target-Kategorie:
PROTACs,RAR/RXR,SNIPERs
Anwendungsbeschreibung:
MCE Product type: Reference compound
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