Lithocholic acid 3-sulfate (disodium), CAS [[64936-81-8]]

Produktübersicht

• Artikelname: Lithocholic acid 3-sulfate (disodium), CAS [[64936-81-8]]
• Artikelnummer: MCE-HY-113238A
• Hersteller Artikelnummer: HY-113238A
• Alternativnummer: MCE-HY-113238A-10MG,MCE-HY-113238A-5MG,MCE-HY-113238A-100MG,MCE-HY-113238A-25MG,MCE-HY-113238A-1MG,MCE-HY-113238A-50MG
• Hersteller: MedchemExpress
• Kategorie: Kits/Assays
• Alternative Synonym: Sulfolithocholic acid (disodium), LCAS (disodium)

Produktbeschreibung

Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC50 values of 41 µM and 42.4 µM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn2+, and 0.88 µM and 0.97 µM in the presence of Zn2+. Lithocholic acid 3-sulfate disodium acts as a RORgammat ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORgammat. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases[1][2].

Produkteigenschaften

• Molekulargewicht: 500.60
• Reinheit: 99.93
• CAS Nummer: [64936-81-8]
• Formel: C24H38Na2O6S
• Target-Kategorie: GPR39,ROR

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Biochemical Assay Reagents