Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC50 values of 41 µM and 42.4 µM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn2+, and 0.88 µM and 0.97 µM in the presence of Zn2+. Lithocholic acid 3-sulfate disodium acts as a RORgammat ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORgammat. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases[1][2].
Molecular Weight:
500.60
Purity:
99.93
CAS Number:
[64936-81-8]
Formula:
C24H38Na2O6S
Target:
GPR39,ROR
Application Notes:
MCE Product type: Biochemical Assay Reagents
* VAT and and shipping costs not included. Errors and price changes excepted
