VTP50469 (mesylate), CAS [[2169919-27-9]] Preis auf Anfrage
Artikelnummer:
MCE-HY-114162B
Hersteller Artikelnummer:
HY-114162B
Alternativnummer:
MCE-HY-114162B-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Alternative Synonym:
SNDX-50469 (mesylate)
VTP50469 mesylate is a potent, and selective Menin-MLL1 inhibitor that effectively targets MLL-rearranged and NPM1c+ leukemia. VTP50469 mesylate selectively kills cell lines with MLL rearrangements and NPM1c+ mutations. VTP50469 mesylate displaces Menin from protein complexes and inhibits MLLs chromatin occupancy at specific genes, leading to significant changes in gene expression, differentiation, and apoptosis. VTP50469 demonstrates dramatic reductions in leukemia burden in patient-derived xenograft models of MLL-r acute myeloid leukemia and MLL-r acute lymphoblastic leukemia, with some mice remaining disease-free for over a year post-treatment.
Molekulargewicht:
823.03
CAS Nummer:
[2169919-27-9]
Formel:
C34H55FN6O10S3
Target-Kategorie:
Apoptosis,Epigenetic Reader Domain
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
