VTP50469 (mesylate), CAS [[2169919-27-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-114162B
Supplier Catalog Number:
HY-114162B
Alternative Catalog Number:
MCE-HY-114162B-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
SNDX-50469 (mesylate)
VTP50469 mesylate is a potent, and selective Menin-MLL1 inhibitor that effectively targets MLL-rearranged and NPM1c+ leukemia. VTP50469 mesylate selectively kills cell lines with MLL rearrangements and NPM1c+ mutations. VTP50469 mesylate displaces Menin from protein complexes and inhibits MLLs chromatin occupancy at specific genes, leading to significant changes in gene expression, differentiation, and apoptosis. VTP50469 demonstrates dramatic reductions in leukemia burden in patient-derived xenograft models of MLL-r acute myeloid leukemia and MLL-r acute lymphoblastic leukemia, with some mice remaining disease-free for over a year post-treatment.
Molecular Weight:
823.03
CAS Number:
[2169919-27-9]
Formula:
C34H55FN6O10S3
Target:
Apoptosis,Epigenetic Reader Domain
Application Notes:
MCE Product type: Reference compound
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