BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 µM in U2OS cells[1].
Molekulargewicht:
469.81
Reinheit:
99.83
CAS Nummer:
[2387510-87-2]
Formel:
C22H24Cl3FN4
Target-Kategorie:
Histone Methyltransferase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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