Octyl-alpha-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of alpha-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-alpha-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD[1].
Molekulargewicht:
258.31
Reinheit:
99.9
CAS Nummer:
[876150-14-0]
Formel:
C13H22O5
Target-Kategorie:
HIF/HIF Prolyl-Hydroxylase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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