Octyl-alpha-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of alpha-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-alpha-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD[1].
Molecular Weight:
258.31
Purity:
99.9
CAS Number:
[876150-14-0]
Formula:
C13H22O5
Target:
HIF/HIF Prolyl-Hydroxylase
Application Notes:
MCE Product type: Reference compound
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