Fluzoparib (SHR3162) is a potent and orally active PARP1 inhibitor (IC50=1.460.72 nM, a cell-free enzymatic assay) with superior antitumor activity. Fluzoparib selectively inhibits the proliferation of homologous recombination repair (HR)-deficient cells, and sensitizes both HR-deficient and HR-proficient cells to cytotoxic agents. Fluzoparib exhibits good pharmacokinetic properties in vivo and can be used for BRCA1/2-mutant relapsed ovarian cancer research[1].
Molekulargewicht:
472.40
Reinheit:
99.96
CAS Nummer:
[1358715-18-0]
Formel:
C22H16F4N6O2
Target-Kategorie:
PARP
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
