Fluzoparib (SHR3162) is a potent and orally active PARP1 inhibitor (IC50=1.460.72 nM, a cell-free enzymatic assay) with superior antitumor activity. Fluzoparib selectively inhibits the proliferation of homologous recombination repair (HR)-deficient cells, and sensitizes both HR-deficient and HR-proficient cells to cytotoxic agents. Fluzoparib exhibits good pharmacokinetic properties in vivo and can be used for BRCA1/2-mutant relapsed ovarian cancer research[1].
Molecular Weight:
472.40
Purity:
99.96
CAS Number:
[1358715-18-0]
Formula:
C22H16F4N6O2
Target:
PARP
Application Notes:
MCE Product type: Reference compound
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