BTT-369 is a CaValpha1CaVbeta3 protein-protein complex antagonist with a Ki of 2.0 µM. BTT-369 inhibits CaV2.2 currents, with an apparent IC50 value of 31 µM. BTT-369 disrupts the interaction between CaValpha1 and CaVbeta3 subunits. BTT-369 reduces the current density of CaV2.2, and shifts the voltage dependence of steady-state inactivation and activation of CaV2.2 to more positive potentials. BTT-369 alleviates mechanical hyperalgesia in a rat model of tibial nerve injury. BTT-369 can be used for the study of neuropathic pain[1].
Molekulargewicht:
580.64
CAS Nummer:
[2413939-96-3]
Formel:
C34H28N8O2
Target-Kategorie:
Calcium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
