BTT-369 is a CaValpha1CaVbeta3 protein-protein complex antagonist with a Ki of 2.0 µM. BTT-369 inhibits CaV2.2 currents, with an apparent IC50 value of 31 µM. BTT-369 disrupts the interaction between CaValpha1 and CaVbeta3 subunits. BTT-369 reduces the current density of CaV2.2, and shifts the voltage dependence of steady-state inactivation and activation of CaV2.2 to more positive potentials. BTT-369 alleviates mechanical hyperalgesia in a rat model of tibial nerve injury. BTT-369 can be used for the study of neuropathic pain[1].
Molecular Weight:
580.64
CAS Number:
[2413939-96-3]
Formula:
C34H28N8O2
Target:
Calcium Channel
Application Notes:
MCE Product type: Reference compound1
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