TAS-4 is a potent and selective mGluR4 positive allosteric modulator with significant anti-Parkinsons disease activity. TAS-4 is able to show efficacy when used alone or in combination with l-DOPA. TAS-4 is able to reverse haloperidol-induced spasticity when administered alone. TAS-4 enhances the contralateral rotation behavior induced by l-DOPA in a dose-dependent manner. TAS-4 combined with low-dose l-DOPA shows anti-Parkinsons effects similar to full-dose l-DOPA without exacerbating abnormal motor side effects[1].
Molekulargewicht:
267.11
CAS Nummer:
[794544-99-3]
Formel:
C12H8Cl2N2O
Target-Kategorie:
iGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
