TAS-4 is a potent and selective mGluR4 positive allosteric modulator with significant anti-Parkinsons disease activity. TAS-4 is able to show efficacy when used alone or in combination with l-DOPA. TAS-4 is able to reverse haloperidol-induced spasticity when administered alone. TAS-4 enhances the contralateral rotation behavior induced by l-DOPA in a dose-dependent manner. TAS-4 combined with low-dose l-DOPA shows anti-Parkinsons effects similar to full-dose l-DOPA without exacerbating abnormal motor side effects[1].
Molecular Weight:
267.11
CAS Number:
[794544-99-3]
Formula:
C12H8Cl2N2O
Target:
iGluR
Application Notes:
MCE Product type: Reference compound
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